As far as the endocannabinoid system, Delta-9 THC only activates the CB1 receptor whereas, Delta-8 THC activates both the CB1 and CB2 receptors. When both receptors are involved there is an associated physical state known as homeostasis, the body’s natural resting state, when it is not in a fight or fight mode. This is the same effect CBD has on the body.
The benefits of Delta-8 are considerably different than those of Delta-9. In studies dating back to 1974 when cannabinoids were being studied by Professor Raphael Mechoulam, he found that Delta-8 is an enormously powerful immune system activator and eliminated nausea in patients who were ill from cancer medications and chemotherapy treatments. Additionally, it was shown in 1995 during a study done in Israel to shrink tumors.
Δ8THC users typically report feeling far more active and outgoing with increased confidence and almost none of the anxiousness and paranoia associated with Δ9THC usage. Δ8THC gives a more manageable “heady” feeling typically allowing for more activity while in use, compared to Δ9THC which tends to be felt more in the body and can often suppress physical activity.
If you are using cannabinoids and want to get stuff done, hang out with friends, or have a video game marathon, Δ8THC may be the better choice. If you’re looking to sit on the couch and watch a movie, Δ9THC may be the way to go.